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1.3. Aims of peak calling algorithms for NGS technologies:
Given the recent developments in the field combined with the theoretical and practical lessons learned from a number of diverse current peak calling algorithms. We formulate the core requirements for a peak calling algorithms for NGS in this manner: In order to keep up with the steadily rising number of experimental protocols that require peak calling algorithms for data-analysis, these algorithms have to be wide-ranging sufficient in order to be applicable across datasets from many different NGS technologies (i.e. ChIP-seq peak calling algorithms applied to MNase-seq, DNase-seq, and ATAC-seq etc.)5. Regardless of the algorithmic and statistical complexity of the data-analysis mission, the implementation needs to be suitable for a general audience.